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CS-W001157 4
Total: USD 88.00

2-(4-Aminobenzyl)aniline

  • CAS No. 1208-52-2

  • Cat. No. CS-W019351
  • Purity≥98%
  • MDL No.MFCD01670227

*For research and further manufacturing use only, not for direct human use.

2-(4-Aminobenzyl)aniline|CS-W019351

Structure of 1208-52-2

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General Information

  • CAS No. 1208-52-2
  • Cat. No. CS-W019351
  • Purity ≥98%
  • MDL No. MFCD01670227
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₄N₂
  • Molecular Weight 198.26
  • Synonym(s) 2,4'-Methylenedianiline
  • SMILES NC1=CC=C(CC2=C(N)C=CC=C2)C=C1

Description

2-(4-Aminobenzyl)aniline features a dual amine architecture with distinct electronic and steric profiles, enabling efficient integration into pharmaceutical intermediates. The para-aminobenzyl moiety enhances solubility and reactivity, while the aniline core provides a robust scaffold for C–N coupling reactions under standard conditions. This compound serves as a key building block in targeted drug discovery pipelines.

Application

2-(4-Aminobenzyl)aniline serves as a versatile building block in medicinal chemistry, enabling the construction of biaryl and heterocyclic scaffolds through standard coupling reactions. Its dual amine functionality provides orthogonal reactivity for sequential derivatization, while the benzyl-linked aniline moiety offers enhanced solubility and metabolic stability in complex molecular architectures. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for high-throughput synthesis and API development workflows.

Synthesis

  • Route1
    • null|null
      50-00-0
    • null|null
      74497-02-2
    • ~64%
    • In-stock
      2-(4-Aminobenzyl)aniline|CS-W019351
      1208-52-2
    • null|null
      101-77-9

    References

    • EP1707557 A1, ; Page/Page column 5-9 ;
  • Route2
    • null|null
      50-00-0
    • null|null
      74497-02-2
    • ~%
    • In-stock
      2-(4-Aminobenzyl)aniline|CS-W019351
      1208-52-2
    • In-stock
      2,2'-Methylenedianiline|CS-0156658
      6582-52-1
    • null|null
      101-77-9

    References

    • US2007/117997 A1, ; Page/Page column 3; 4 ;
  • Route3
    • null|null
      50-00-0
    • null|null
      74497-02-2
    • ~%
    • In-stock
      2-(4-Aminobenzyl)aniline|CS-W019351
      1208-52-2

    References

    • Tetrahedron, , vol. 25, p. 847 - 853

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅱ
Hazard Statements : H301+H311+H331-H317-H319-H341-H410
Precautionary Statements : P261-P273-P280

Quality Control

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   2.4418
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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