2-Chloro-5-aminomethylthiazole

Name: 2-Chloro-5-aminomethylthiazole
Brand: ChemScene
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CAS No. 120740-08-1
Cat. No. CS-W005024
Purity≥95%
MDL No.MFCD08705904

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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2-Chloro-5-aminomethylthiazole|CS-W005024

Structure of 120740-08-1

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Description

2-Chloro-5-aminomethylthiazole features a reactive chloro substituent and a primary amine handle, enabling straightforward functionalization in medicinal chemistry. This bench-stable heterocycle integrates readily into bioactive scaffolds, particularly in kinase inhibitor development and targeted drug discovery workflows.

Application

2-Chloro-5-aminomethylthiazole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the thiazole ring via nucleophilic substitution. The chloro group facilitates coupling reactions with amines, thiols, and heterocycles under mild conditions, while the aminomethyl side chain offers a handle for further derivatization. Bench-stable and compatible with standard purification methods, it functions efficiently in the synthesis of thiazole-based pharmacophores and API intermediates.

General Information

CAS No. 120740-08-1
Cat. No. CS-W005024
Purity ≥95%
MDL No. MFCD08705904
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₅ClN₂S
Molecular Weight 148.61
Synonym(s) 1-(2-chloro-1,3-thiazol-5-yl)methanamine
SMILES ClC1=NC=C(S1)CN

Computational Chemistry Data

TPSA 38.91
LogP 1.2552
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

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2-Chloro-5-aminomethylthiazole

CAS No. 120740-08-1

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