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CS-W001157 4
Total: USD 88.00

2-Chloro-5-aminomethylthiazole

  • CAS No. 120740-08-1

  • Cat. No. CS-W005024
  • Molecule weight148.61
  • Purity≥95%
  • MDL No.MFCD08705904

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-aminomethylthiazole|CS-W005024

Structure of 120740-08-1

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General Information

  • CAS No. 120740-08-1
  • Cat. No. CS-W005024
  • Purity ≥95%
  • MDL No. MFCD08705904
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅ClN₂S
  • Molecular Weight 148.61
  • Synonym(s) 1-(2-chloro-1,3-thiazol-5-yl)methanamine
  • SMILES ClC1=NC=C(S1)CN

Description

2-Chloro-5-aminomethylthiazole features a reactive chloro substituent and a primary amine handle, enabling straightforward functionalization in medicinal chemistry. This bench-stable heterocycle integrates readily into bioactive scaffolds, particularly in kinase inhibitor development and targeted drug discovery workflows.

Application

2-Chloro-5-aminomethylthiazole serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the thiazole ring via nucleophilic substitution. The chloro group facilitates coupling reactions with amines, thiols, and heterocycles under mild conditions, while the aminomethyl side chain offers a handle for further derivatization. Bench-stable and compatible with standard purification methods, it functions efficiently in the synthesis of thiazole-based pharmacophores and API intermediates.

Synthesis

  • Route1

    References

    • Wang, Qingmin; Li, Heng; Li, Yonghong; Huang, Runqiu Journal of Agricultural and Food Chemistry, 2004 , vol. 52, # 7 p. 1918 - 1922
  • Route2
    • In-stock
      2-Chloro-5-(chloromethyl)thiazole|CS-W002731
      105827-91-6
    • ~43%
    • null|null
      434902-57-5
    • In-stock
      2-Chloro-5-aminomethylthiazole|CS-W005024
      120740-08-1

    References

    • WO2005/123704 A1, ; Page/Page column 25-26 ;
  • Route3
    • null|null
      872165-33-8
    • ~81%
    • null|null
      434902-57-5
    • In-stock
      2-Chloro-5-aminomethylthiazole|CS-W005024
      120740-08-1

    References

    • WO2005/123704 A1, ; Page/Page column 14-23; 26-29 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.2552
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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