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CS-W001157 4
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tert-Butyl 4-(bromomethyl)-4-fluoropiperidine-1-carboxylate

  • CAS No. 1207176-24-6

  • Cat. No. CS-0037092
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 4-(bromomethyl)-4-fluoropiperidine-1-carboxylate|CS-0037092

Structure of 1207176-24-6

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General Information

  • CAS No. 1207176-24-6
  • Cat. No. CS-0037092
  • Purity ≥95%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₉BrFNO₂
  • Molecular Weight 296.18
  • Synonym(s) 1-Piperidinecarboxylic acid, 4-(bromomethyl)-4-fluoro-, 1,1-dimethylethyl ester
  • SMILES CC(C)(C)OC(=O)N1CCC(CC1)(CBr)F

Description

tert-Butyl 4-(bromomethyl)-4-fluoropiperidine-1-carboxylate delivers a reactive bromomethyl handle adjacent to a fluorinated piperidine scaffold, enabling site-specific functionalization in medicinal chemistry. The bench-stable, moisture-tolerant ester facilitates efficient coupling reactions under mild conditions, streamlining the synthesis of complex fluorinated heterocycles.

Application

tert-Butyl 4-(bromomethyl)-4-fluoropiperidine-1-carboxylate serves as a versatile building block for the synthesis of fluorinated piperidine scaffolds. The bromomethyl group enables efficient nucleophilic substitution reactions, while the 4-fluoro substituent imparts enhanced metabolic stability and modulates electronic properties. The tert-butyl carbamate protection ensures compatibility with diverse reaction conditions, facilitating straightforward deprotection and functionalization. This reagent offers excellent bench stability and ease of purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   3.1205
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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