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CS-W001157 4
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10H-Phenothiazine 5-oxide

  • CAS No. 1207-71-2

  • Cat. No. CS-0527404
  • Purity≥98%
  • MDL No.MFCD00053824

*For research and further manufacturing use only, not for direct human use.

10H-Phenothiazine 5-oxide|CS-0527404

Structure of 1207-71-2

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General Information

  • CAS No. 1207-71-2
  • Cat. No. CS-0527404
  • Purity ≥98%
  • MDL No. MFCD00053824
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₉NOS
  • Molecular Weight 215.27
  • Synonym(s) Promethazine Impurity 13
  • SMILES O=S1C2=C(NC3=C1C=CC=C3)C=CC=C2

Description

10H-Phenothiazine 5-oxide features a sulfoxide functionality at the 5-position of the phenothiazine core, conferring enhanced polarity and redox activity. This bench-stable compound integrates readily into electron-rich scaffolds for applications in organic electronics and medicinal chemistry. The oxidized sulfur center enables selective reactivity in functionalization workflows.

Application

10H-Phenothiazine 5-oxide serves as a versatile scaffold for the synthesis of biologically active heterocycles and functional materials. Its oxidized sulfur center enhances polarity and reactivity, enabling efficient derivatization at the 5-position while maintaining bench stability. The compound functions as a key building block in medicinal chemistry campaigns targeting CNS agents and antioxidant systems, offering excellent functional group tolerance and compatibility with standard coupling protocols.

Synthesis

  • Route1

    References

    • Gomurashvili, Zaza; Crivello, James V. Macromolecules, 2002 , vol. 35, # 8 p. 2962 - 2969
  • Route2
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    • ~%
    • In-stock
      10H-Phenothiazine 5-oxide|CS-0527404
      1207-71-2

    References

    • Fujihara, Hisashi; Fuke, Shunichi; Yoshihara, Masakuni; Maeshima, Toshihisa Chemistry Letters, 1981 , p. 1271 - 1272
  • Route3

    References

    • Matsui; Miyamoto; Shibata; Takase Bulletin of the Chemical Society of Japan, 1984 , vol. 57, # 9 p. 2526 - 2530

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H303-H317-H402
Precautionary Statements : P261-P272-P273-P280-P302+P352-P362+P364-P501

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Computational Chemistry Data

  • TPSA   29.1
  • LogP   2.9103
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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