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CS-W001157 4
Total: USD 88.00

2-Chloro-5-(difluoromethoxy)pyridine

  • CAS No. 1206980-28-0

  • Cat. No. CS-D0408
  • Purity≥98%
  • MDL No.MFCD13185849

*For research and further manufacturing use only, not for direct human use.

2-Chloro-5-(difluoromethoxy)pyridine|CS-D0408

Structure of 1206980-28-0

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General Information

  • CAS No. 1206980-28-0
  • Cat. No. CS-D0408
  • Purity ≥98%
  • MDL No. MFCD13185849
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClF₂NO
  • Molecular Weight 179.55
  • Synonym(s) None
  • SMILES FC(F)OC1=CN=C(Cl)C=C1

Description

2-Chloro-5-(difluoromethoxy)pyridine features a difluoromethoxy group that enhances metabolic stability and modulates electronic properties within heterocyclic scaffolds. This electron-deficient pyridine serves as a key building block in agrochemical and pharmaceutical synthesis, enabling efficient coupling reactions under standard conditions.

Application

2-Chloro-5-(difluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its reactive pyridyl chloride moiety. The difluoromethoxy group enhances metabolic stability and modulates lipophilicity, while the compound exhibits excellent bench stability and compatibility with standard purification techniques.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   2.3364
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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