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CS-W001157 4
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6-Chloro-1H-pyrazolo[4,3-c]pyridin-3-amine

  • CAS No. 1206979-75-0

  • Cat. No. CS-0163691
  • Molecule weight168.58
  • Purity≥97%
  • MDL No.MFCD22549635

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1H-pyrazolo[4,3-c]pyridin-3-amine|CS-0163691

Structure of 1206979-75-0

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General Information

  • CAS No. 1206979-75-0
  • Cat. No. CS-0163691
  • Purity ≥97%
  • MDL No. MFCD22549635
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClN₄
  • Molecular Weight 168.58
  • Synonym(s) None
  • SMILES NC1=NNC2=C1C=NC(Cl)=C2

Description

6-Chloro-1H-pyrazolo[4,3-c]pyridin-3-amine delivers a rigid, electron-deficient heterocyclic scaffold ideal for medicinal chemistry. This bench-stable compound integrates readily into kinase inhibitor scaffolds and engages in efficient cross-coupling reactions. The chloro group enables further functionalization, while the pyrazolopyridine core supports hydrogen bonding interactions in target binding.

Application

6-Chloro-1H-pyrazolo[4,3-c]pyridin-3-amine serves as a versatile building block for medicinal chemistry and heterocyclic synthesis. The chloro group enables palladium-catalyzed cross-coupling reactions, while the primary amine facilitates derivatization via acylation, alkylation, or Ullmann-type coupling. This scaffold exhibits excellent bench stability and compatibility with common protecting group strategies, making it ideal for iterative synthesis of kinase inhibitors and other bioactive molecules.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.59
  • LogP   1.1935
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   0

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