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Structure of 1206975-33-8
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2-Chloro-4-(trifluoromethoxy)pyridine features a trifluoromethoxy group that enhances electron-withdrawal and metabolic stability, while the chlorine substituent enables efficient coupling in cross-coupling reactions. This pyridine scaffold serves as a key building block in pharmaceutical synthesis, particularly for kinase inhibitors and agrochemicals.
2-Chloro-4-(trifluoromethoxy)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-established reactivity at the C2 position. The trifluoromethoxy group imparts enhanced metabolic stability and lipophilicity, while the chlorine atom offers reliable functionalization potential under standard conditions. Its bench-stable nature and compatibility with diverse reaction partners make it a practical choice for constructing complex heterocyclic scaffolds and API intermediates.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H315-H318-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: