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Structure of 1206972-19-1
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4-(Difluoromethoxy)pyridin-2-amine features a pyridin-2-amine core appended with a difluoromethoxy group at the 4-position, delivering enhanced electron-withdrawing character and metabolic stability. This substitution pattern imparts favorable solubility and compatibility with diverse synthetic transformations. The molecule integrates readily into bioactive scaffolds, particularly in medicinal chemistry applications targeting kinase inhibition and CNS-penetrant therapeutics.
4-(Difluoromethoxy)pyridin-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling reactions. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the pyridin-2-amine moiety provides a robust handle for further functionalization via Suzuki-Miyaura, Buchwald-Hartwig, or electrophilic substitution. Bench-stable and readily purified, it functions effectively in multi-step syntheses targeting kinase inhibitors and CNS-active compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: