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Structure of 1206459-86-0
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4-(Trifluoromethyl)pyrimidine-2-carbonitrile features a trifluoromethyl group and a nitrile moiety positioned ortho to each other on the pyrimidine ring, creating a highly electron-deficient heterocyclic scaffold. This configuration enhances its utility in coupling reactions and as a building block for bioactive molecules. The compound exhibits stability under standard bench conditions and compatibility with diverse synthetic transformations.
4-(Trifluoromethyl)pyrimidine-2-carbonitrile serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via cross-coupling and nucleophilic substitution reactions. Its dual electron-withdrawing groups—trifluoromethyl and nitrile—enhance reactivity while maintaining bench stability, facilitating functionalization at multiple sites. The molecule exhibits excellent compatibility with standard synthetic protocols, offering high yields and straightforward purification, making it ideal for rapid lead optimization and API intermediate synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: