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CS-W001157 4
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4,6-Dichloro-3-methyl-1H-pyrazolo[4,3-c]pyridine

  • CAS No. 120422-90-4

  • Cat. No. CS-0134774
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4,6-Dichloro-3-methyl-1H-pyrazolo[4,3-c]pyridine|CS-0134774

Structure of 120422-90-4

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General Information

  • CAS No. 120422-90-4
  • Cat. No. CS-0134774
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅Cl₂N₃
  • Molecular Weight 202.04
  • Synonym(s) 4,6-dichloro-3-methylpyrazolopyridine
  • SMILES CC1=NNC2=C1C(Cl)=NC(Cl)=C2

Description

4,6-Dichloro-3-methyl-1H-pyrazolo[4,3-c]pyridine features a fused pyrazolo-pyridine core with dual chlorines at positions 4 and 6, enhancing electrophilic reactivity. The methyl group at C3 provides steric stabilization and improves solubility. This scaffold serves as a key building block for kinase inhibitors and bioactive heterocycles in medicinal chemistry.

Application

4,6-Dichloro-3-methyl-1H-pyrazolo[4,3-c]pyridine serves as a versatile building block for the synthesis of bioactive heterocycles, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. The dichloro substitution pattern facilitates selective derivatization at C4 or C6 positions, while the methyl group enhances solubility and metabolic stability. Its bench-stable crystalline form simplifies handling and purification in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   41.57
  • LogP   2.57312
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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