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CS-W001157 4
Total: USD 88.00

4'-Amino-[1,1'-biphenyl]-4-ol

  • CAS No. 1204-79-1

  • Cat. No. CS-0133969
  • Purity≥97%
  • MDL No.MFCD00463439

*For research and further manufacturing use only, not for direct human use.

4'-Amino-[1,1'-biphenyl]-4-ol|CS-0133969

Structure of 1204-79-1

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General Information

  • CAS No. 1204-79-1
  • Cat. No. CS-0133969
  • Purity ≥97%
  • MDL No. MFCD00463439
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₁NO
  • Molecular Weight None
  • Synonym(s) 4-Amino-4'-hydroxybiphenyl
  • SMILES OC1=CC=C(C2=CC=C(N)C=C2)C=C1

Description

4'-Amino-[1,1'-biphenyl]-4-ol features a dual functional group architecture: an electron-rich amino moiety and a phenolic hydroxyl group positioned at opposing termini of a rigid biphenyl scaffold. This arrangement enables direct integration into conjugated systems for materials science and pharmaceutical applications, where controlled solubility and enhanced intermolecular interactions are critical.

Application

4'-Amino-[1,1'-biphenyl]-4-ol serves as a versatile building block in the synthesis of functionalized biaryls and heterocyclic scaffolds. Its ortho-directed reactivity enables efficient coupling processes, while the amino and phenolic functionalities offer complementary handles for derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic campaigns in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Hanaoka, Kenjiro; Kikuchi, Kazuya; Terai, Takuya; Komatsu, Toru; Nagano, Tetsuo Chemistry - A European Journal, 2008 , vol. 14, # 3 p. 987 - 995
  • Route2
    • null|null
      106-41-2
    • (4-Aminophenyl)boronic acid|CS-0174693
      89415-43-0
    • ~%
    • In-stock
      4'-Amino-[1,1'-biphenyl]-4-ol|CS-0133969
      1204-79-1

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 2 p. 824 - 828
  • Route3
    • 4'-Nitro-[1,1'-biphenyl]-4-amine|CS-0312908
      1211-40-1
    • ~%
    • In-stock
      4'-Amino-[1,1'-biphenyl]-4-ol|CS-0133969
      1204-79-1

    References

    • Mutation Research - Genetic Toxicology Testing and Biomonitoring of Environmental or Occupational Exposure, , vol. 320, # 1-2 p. 45 - 58

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   2.6414
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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