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CS-W001157 4
Total: USD 88.00

3-Bromo-1-methyl-1H-indazol-6-amine

  • CAS No. 1203181-56-9

  • Cat. No. CS-0051491
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Bromo-1-methyl-1H-indazol-6-amine|CS-0051491

Structure of 1203181-56-9

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General Information

  • CAS No. 1203181-56-9
  • Cat. No. CS-0051491
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈BrN₃
  • Molecular Weight 226.07
  • Synonym(s) None
  • SMILES CN1N=C(Br)C2=CC=C(N)C=C12

Description

3-Bromo-1-methyl-1H-indazol-6-amine features a brominated indazoline core with a methylated nitrogen and a primary amine at the 6-position, enabling direct coupling in Suzuki-Miyaura and Buchwald-Hartwig reactions. This bench-stable scaffold integrates readily into bioactive heterocycles for medicinal chemistry applications.

Application

3-Bromo-1-methyl-1H-indazol-6-amine serves as a versatile building block for constructing biologically active heterocycles, enabling palladium-catalyzed cross-coupling reactions with broad functional group tolerance. The bromo group facilitates efficient C–C and C–N bond formation, while the indazol-6-amine scaffold provides a rigid, polar platform suitable for medicinal chemistry optimization. Bench-stable and readily purified, it functions effectively in standard coupling protocols and supports scalable synthesis of kinase inhibitors and other pharmaceutical intermediates.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   1.918
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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