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CS-W001157 4
Total: USD 88.00

5-Fluoro-2-iodobenzoic acid methyl ester

  • CAS No. 1202897-48-0

  • Cat. No. CS-0032319
  • Purity≥97%
  • MDL No.MFCD12965043
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Fluoro-2-iodobenzoic acid methyl ester|CS-0032319

Structure of 1202897-48-0

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Description

5-Fluoro-2-iodobenzoic acid methyl ester features a strategically positioned fluorine atom and iodine substituent on the aromatic ring, enabling selective cross-coupling reactions. The methyl ester group enhances solubility and reactivity in transition metal-catalyzed transformations. This compound serves as a key intermediate for synthesizing bioactive molecules in medicinal chemistry and materials science.

Application

5-Fluoro-2-iodobenzoic acid methyl ester serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. The iodine moiety facilitates reliable Suzuki, Stille, and Negishi couplings, while the fluorinated benzene core enhances metabolic stability in downstream applications. Bench-stable and readily purified by flash chromatography, it functions effectively in medicinal chemistry and materials synthesis workflows.

General Information

  • CAS No. 1202897-48-0
  • Cat. No. CS-0032319
  • Purity ≥97%
  • MDL No. MFCD12965043
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆FIO₂
  • Molecular Weight 280.03
  • Synonym(s) Methyl 5-fluoro-2-iodobenzoate
  • SMILES COC(C1=C(I)C=CC(F)=C1)=O

Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.2169
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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