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CS-W001157 4
Total: USD 88.00

5-Methylthiazole-4-carboxylic acid

  • CAS No. 120237-76-5

  • Cat. No. CS-W004929
  • Purity≥98%
  • MDL No.MFCD06738813

*For research and further manufacturing use only, not for direct human use.

5-Methylthiazole-4-carboxylic acid|CS-W004929

Structure of 120237-76-5

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General Information

  • CAS No. 120237-76-5
  • Cat. No. CS-W004929
  • Purity ≥98%
  • MDL No. MFCD06738813
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅NO₂S
  • Molecular Weight 143.16
  • Synonym(s) 5-METHYL-1,3-THIAZOLE-4-CARBOXYLIC ACID
  • SMILES O=C(C1=C(C)SC=N1)O

Description

5-Methylthiazole-4-carboxylic acid features a thiazole core with complementary electron-rich and electron-deficient moieties, enabling robust integration into pharmaceutical scaffolds. The methyl group enhances lipophilicity and metabolic stability, while the carboxylic acid facilitates conjugation via amide or ester linkages. This compound serves as a key building block in bioactive molecule synthesis.

Application

5-Methylthiazole-4-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to thiazole-based scaffolds prevalent in medicinal chemistry. Its carboxylic acid functionality facilitates direct coupling reactions and derivatization under standard conditions, while the methyl group provides a handle for further functionalization. The compound exhibits good bench stability and is compatible with common purification methods, making it well-suited for use in iterative synthetic sequences and API intermediate development.

Synthesis

  • Route1

    References

    • TAKEDA PHARMACEUTICAL COMPANY LIMITED Patent: US2009/137595 A1, 2009 ;
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 16 p. 3732 - 3736

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.14972
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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