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CS-W001157 4
Total: USD 88.00

(3-(Trifluoromethyl)-1H-pyrazol-4-yl)boronic acid

  • CAS No. 1202054-12-3

  • Cat. No. CS-0080401
  • Purity≥95%
  • MDL No.MFCD07375369
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(3-(Trifluoromethyl)-1H-pyrazol-4-yl)boronic acid|CS-0080401

Structure of 1202054-12-3

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Description

This trifluoromethyl-substituted pyrazole boronic acid integrates a robust, electron-deficient heterocyclic scaffold with a reactive boronate handle. The para-trifluoromethyl group enhances metabolic stability and modulates electronic properties, enabling efficient Suzuki-Miyaura coupling under standard conditions. Designed for streamlined access to bioactive arylated heterocycles in medicinal chemistry and materials science applications.

Application

(3-(Trifluoromethyl)-1H-pyrazol-4-yl)boronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its trifluoromethyl group imparts enhanced metabolic stability and lipophilicity, making it valuable for constructing bioactive heterocycles. The boronic acid functionality offers excellent bench stability, straightforward purification, and broad functional group tolerance, facilitating its use in medicinal chemistry and process-scale synthesis.

General Information

  • CAS No. 1202054-12-3
  • Cat. No. CS-0080401
  • Purity ≥95%
  • MDL No. MFCD07375369
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₄BF₃N₂O₂
  • Molecular Weight 179.89
  • Synonym(s) 5-Trifluoromethyl-1h-pyrazol-4-ylboronic acid
  • SMILES FC(F)(F)C1=NNC=C1B(O)O

Computational Chemistry Data

  • TPSA   69.14
  • LogP   -0.8917
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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