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CS-W001157 4
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tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate

  • CAS No. 120157-97-3

  • Cat. No. CS-0021342
  • Purity≥97%
  • MDL No.MFCD08443684

*For research and further manufacturing use only, not for direct human use.

tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate|CS-0021342

Structure of 120157-97-3

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General Information

  • CAS No. 120157-97-3
  • Cat. No. CS-0021342
  • Purity ≥97%
  • MDL No. MFCD08443684
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₈BrNO₂
  • Molecular Weight 300.20
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)NCCC1=CC=C(Br)C=C1

Description

tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate is a bench-stable, moisture-tolerant building block featuring a brominated aromatic handle and a removable carbamate protecting group. This compound integrates readily into Suzuki-Miyaura coupling workflows and serves as a versatile precursor for functionalized phenethyl derivatives in medicinal chemistry and materials synthesis.

Application

tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate serves as a stable, bench-ready building block for the synthesis of bioactive molecules. Its orthogonal carbamate protection enables selective functionalization, while the pendant bromophenyl group facilitates palladium-catalyzed cross-coupling reactions. The tert-butyl carbamate moiety offers excellent stability under basic conditions and simplifies purification, making it well-suited for iterative synthetic strategies in medicinal chemistry and API development.

Synthesis

  • Route1

    References

    • Hydra Biosciences Patent: US2007/219222 A1, 2007 ; Location in patent: Page/Page column 47 ;
  • Route2

    References

    • Caddick, Stephen; Judd, Duncan B.; Lewis, Alexandra K. De K.; Reich, Melanie T.; Williams, Meredith R. V. Tetrahedron, 2003 , vol. 59, # 29 p. 5417 - 5423
  • Route3
    • In-stock
      ZH8651|CS-W009109
      73918-56-6
    • null|null
      41840-28-2
    • ~91%
    • In-stock
      tert-Butyl N-[2-(4-bromophenyl)ethyl]carbamate|CS-0021342
      120157-97-3

    References

    • Tanaka, Ken-Ichi; Yoshifuji, Shigeyuki; Nitta, Yoshihiro Chemical & Pharmaceutical Bulletin, 1988 , vol. 36, # 8 p. 3125 - 3129

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.33
  • LogP   3.5163
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   3

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