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CS-W001157 4
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5-Methyl-1H-indazole-3-carboxylic acid

  • CAS No. 1201-24-7

  • Cat. No. CS-W005096
  • Purity≥98%
  • MDL No.MFCD05663986

*For research and further manufacturing use only, not for direct human use.

5-Methyl-1H-indazole-3-carboxylic acid|CS-W005096

Structure of 1201-24-7

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General Information

  • CAS No. 1201-24-7
  • Cat. No. CS-W005096
  • Purity ≥98%
  • MDL No. MFCD05663986
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈N₂O₂
  • Molecular Weight 176.17
  • Synonym(s) 5-METHYLINDAZOLE-3-CARBOXYLIC ACID
  • SMILES C1=C(C=CC2=C1C(=N[NH]2)C(=O)O)C

Description

5-Methyl-1H-indazole-3-carboxylic acid features a fused bicyclic core with a methyl group at the 5-position and a carboxylic acid at the 3-position, offering enhanced solubility and metabolic stability. This scaffold integrates readily into bioactive molecules, serving as a key building block in medicinal chemistry for kinase inhibitors and targeted therapeutics.

Application

5-Methyl-1H-indazole-3-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard amide coupling and electrophilic substitution reactions. Its well-defined functional group pattern—comprising a carboxylic acid at C3 and a methyl group at C5—supports orthogonal reactivity and facilitates purification via crystallization or chromatography. The scaffold exhibits bench stability and compatibility with common protecting group strategies, making it suitable for iterative synthesis workflows in API development.

Synthesis

  • Route1

    References

    • Johnson, Barry L.; Rodgers, James D. Synthetic Communications, 2005 , vol. 35, # 20 p. 2681 - 2684
  • Route2

    References

    • Johnson, Barry L.; Rodgers, James D. Synthetic Communications, 2005 , vol. 35, # 20 p. 2681 - 2684

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

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Computational Chemistry Data

  • TPSA   65.98
  • LogP   1.56952
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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