Fmoc-D-Lys(N3)-OH

Name: Fmoc-D-Lys(N3)-OH
Brand: ChemScene
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CAS No. 1198791-53-5
Cat. No. CS-0617878
Purity≥97%
MDL No.MFCD18427293

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 1198791-53-5
Cat. No. CS-0617878
Purity ≥97%
MDL No. MFCD18427293
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₂N₄O₄
Molecular Weight 394.42
Synonym(s) None
SMILES O=C(O)[C@@H](CCCCN=[N+]=[N-])NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

Fmoc-D-Lys(N3)-OH is a chiral, Nα-Fmoc-protected amino acid derivative featuring a trifunctional side chain with a terminal azide group. This configuration enables site-specific conjugation via copper-catalyzed or strain-promoted azide-alkyne cycloaddition, making it ideal for bioconjugation and peptide-based drug discovery workflows. The D-stereoisomer enhances metabolic stability in biological applications.

Application

Fmoc-D-Lys(N3)-OH serves as a key building block for the synthesis of D-amino acid-containing peptides and peptidomimetics. The azide group enables efficient copper-catalyzed or strain-promoted click chemistry, facilitating site-specific conjugation in bioconjugation and combinatorial library development. The Fmoc group provides orthogonal protection for amine functionality during solid-phase peptide synthesis, while the side-chain azide offers high stability and compatibility with standard purification methods.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 124.39
LogP 4.4589
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 9

Other Classifications

Life Science Click Chemistry Reagents Azide

Life Science Amino Acids and their Derivatives Leucine and derivatives

Life Science ADC Related Compound ADC Linker

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Azide

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Pharmaceutical Development and Drug Discovery Research Conjugation Chemistry/Click Chemistry Azides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Chemical Biology Conjugation Chemistry/Click Chemistry Azides

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Cross-Linkers

Key Words

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Fmoc-D-Lys(N3)-OH

CAS No. 1198791-53-5

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