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CS-W001157 4
Total: USD 88.00

(4-Amino-3-methoxyphenyl)dimethylphosphine oxide

  • CAS No. 1197956-03-8

  • Cat. No. CS-0133801
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(4-Amino-3-methoxyphenyl)dimethylphosphine oxide|CS-0133801

Structure of 1197956-03-8

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General Information

  • CAS No. 1197956-03-8
  • Cat. No. CS-0133801
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₄NO₂P
  • Molecular Weight 199.19
  • Synonym(s) None
  • SMILES NC1=CC=C(P(C)(C)=O)C=C1OC

Description

This dimethylphosphine oxide features a 4-amino-3-methoxyphenyl group, delivering enhanced solubility and stability in polar solvents. The phosphine oxide moiety provides strong coordination ability while maintaining bench-stable handling characteristics. Ideal for catalytic applications requiring electron-rich yet moisture-tolerant ligands.

Application

(4-Amino-3-methoxyphenyl)dimethylphosphine oxide serves as a versatile phosphine-based building block in transition-metal-catalyzed cross-coupling reactions. Its electron-donating amino and methoxy groups enhance reactivity while the phosphine oxide functionality provides stability and facilitates purification. This compound enables efficient Pd-catalyzed C–C and C–heteroatom bond formations, particularly in the synthesis of functionalized biaryl and heterocyclic scaffolds common in medicinal chemistry.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.5254
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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