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1-(3-Aminophenyl)propan-1-one

  • CAS No. 1197-05-3

  • Cat. No. CS-0188035
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(3-Aminophenyl)propan-1-one|CS-0188035

Structure of 1197-05-3

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General Information

  • CAS No. 1197-05-3
  • Cat. No. CS-0188035
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO
  • Molecular Weight 149.19
  • Synonym(s) 3-aminopropiophenone
  • SMILES CCC(=O)C1=CC(=CC=C1)N

Description

1-(3-Aminophenyl)propan-1-one features a conjugated aryl ketone scaffold with a para-amino substituent, enabling direct incorporation into bioactive molecule scaffolds. The amine group facilitates derivatization via acylation or coupling reactions, while the ketone offers electrophilic reactivity for nucleophilic addition. This dual functionality supports rapid access to pharmaceutical intermediates and functionalized aromatic systems under standard conditions.

Application

1-(3-Aminophenyl)propan-1-one serves as a versatile building block for pharmaceutical intermediates, enabling efficient construction of biologically relevant scaffolds. Its amine and ketone functionalities offer orthogonal reactivity for coupling, cyclization, and derivatization under standard conditions. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis in medicinal chemistry campaigns.

Synthesis

  • Route1
    • null|null
      17408-16-1
    • ~%
    • In-stock
      1-(3-Aminophenyl)propan-1-one|CS-0188035
      1197-05-3

    References

    • Pratesi; Grana; Villa Farmaco, Edizione Scientifica, 1973 , vol. 28, # 10 p. 753 - 765
  • Route2

    References

    • Vo, Giang D.; Hartwig, John F. Journal of the American Chemical Society, 2009 , vol. 131, # 31 p. 11049 - 11061
  • Route3
    • null|null
      93-55-0
    • ~%
    • In-stock
      1-(3-Aminophenyl)propan-1-one|CS-0188035
      1197-05-3

    References

    • Marques, Carlos Alberto; Selva, Maurizio; Tundo, Pietro Journal of Organic Chemistry, 1994 , vol. 59, # 14 p. 3830 - 3837

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.8615
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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