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CS-W001157 4
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4-(3-Fluorophenyl)-1H-pyrazole

  • CAS No. 1196145-51-3

  • Cat. No. CS-0617889
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD13190108

*For research and further manufacturing use only, not for direct human use.

4-(3-Fluorophenyl)-1H-pyrazole|CS-0617889

Structure of 1196145-51-3

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General Information

  • CAS No. 1196145-51-3
  • Cat. No. CS-0617889
  • Purity ≥95%
  • MDL No. MFCD13190108
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇FN₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES FC1=CC(C2=CNN=C2)=CC=C1

Description

4-(3-Fluorophenyl)-1H-pyrazole features a fluorinated aromatic ring integrated into a pyrazole core, enhancing electron-withdrawing character and metabolic stability. This scaffold serves as a key building block in medicinal chemistry, enabling targeted interactions in kinase inhibitors and CNS-active compounds.

Application

4-(3-Fluorophenyl)-1H-pyrazole serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and functionalization reactions. Its fluorinated aryl group enhances metabolic stability and modulates electronic properties, while the pyrazole core offers hydrogen-bonding capacity and structural rigidity. The compound exhibits good bench stability and is readily purified by column chromatography, facilitating integration into multi-step synthetic sequences for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.2158
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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