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tert-Butyl (S)-2-amino-3,3-dimethylbutanoate hydrochloride

  • CAS No. 119483-45-3

  • Cat. No. CS-0134486
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (S)-2-amino-3,3-dimethylbutanoate hydrochloride|CS-0134486

Structure of 119483-45-3

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General Information

  • CAS No. 119483-45-3
  • Cat. No. CS-0134486
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₂ClNO₂
  • Molecular Weight 223.74
  • Synonym(s) (s)-Tert-butyl 2-amino-3,3-dimethylbutanoate hydrochloride
  • SMILES N[C@@H](C(C)(C)C)C(OC(C)(C)C)=O.[H]Cl

Description

tert-Butyl (S)-2-amino-3,3-dimethylbutanoate hydrochloride delivers a chiral, sterically hindered amino acid surrogate with enhanced stability. The tert-butyl ester group ensures excellent solubility in organic solvents, while the hydrochloride salt form enables straightforward handling and purification. This compound serves as a key intermediate in asymmetric synthesis, particularly for peptide mimetics and bioactive molecule construction under standard bench conditions.

Application

tert-Butyl (S)-2-amino-3,3-dimethylbutanoate hydrochloride serves as a chiral building block for peptidomimetics and bioactive heterocycles. Its tert-butyl ester group enables facile deprotection under mild acidic conditions, while the protected amine and sterically hindered quaternary center provide excellent stability and functional group tolerance in multistep syntheses. The (S)-configuration ensures high stereochemical fidelity in asymmetric synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   2.1233
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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