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CS-W001157 4
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2-Amino-5-bromo-3-methylphenol

  • CAS No. 1194760-84-3

  • Cat. No. CS-0188033
  • Purity≥96%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Amino-5-bromo-3-methylphenol|CS-0188033

Structure of 1194760-84-3

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General Information

  • CAS No. 1194760-84-3
  • Cat. No. CS-0188033
  • Purity ≥96%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BrNO
  • Molecular Weight 202.05
  • Synonym(s) None
  • SMILES OC1=CC(Br)=CC(C)=C1N

Description

2-Amino-5-bromo-3-methylphenol features a strategically positioned amino group adjacent to a bromine substituent, enabling selective coupling reactions. The methyl group enhances solubility and steric profile, while the phenolic hydroxyl supports hydrogen bonding in synthetic intermediates. This scaffold serves as a key building block for bioactive molecules and functional materials under standard conditions.

Application

2-Amino-5-bromo-3-methylphenol serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the amino and phenolic positions. Its bromo group facilitates palladium-catalyzed cross-coupling reactions, while the methyl and hydroxyl functionalities offer orthogonal reactivity for derivatization. The compound exhibits good bench stability and is readily purified by crystallization, supporting efficient integration into multi-step syntheses of heterocyclic scaffolds and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.25
  • LogP   2.04532
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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