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CS-W001157 4
Total: USD 88.00

2-Bromo-4-(methylsulfonyl)pyridine

  • CAS No. 1193244-93-7

  • Cat. No. CS-0094293
  • Purity≥97%
  • MDL No.MFCD28402467

*For research and further manufacturing use only, not for direct human use.

2-Bromo-4-(methylsulfonyl)pyridine|CS-0094293

Structure of 1193244-93-7

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General Information

  • CAS No. 1193244-93-7
  • Cat. No. CS-0094293
  • Purity ≥97%
  • MDL No. MFCD28402467
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆BrNO₂S
  • Molecular Weight 236.09
  • Synonym(s) None
  • SMILES O=S(C1=CC(Br)=NC=C1)(C)=O

Description

2-Bromo-4-(methylsulfonyl)pyridine features a bromine atom at the 2-position and a methylsulfonyl group at the 4-position on a pyridine ring, enabling selective cross-coupling reactions. The electron-deficient pyridine core enhances reactivity in palladium-catalyzed transformations, while the sulfonyl moiety improves solubility and stability under standard conditions.

Application

2-Bromo-4-(methylsulfonyl)pyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromide and electron-withdrawing methylsulfonyl group. The pyridine core provides ortho-directing capability, while the sulfone moiety enhances solubility and metabolic stability. Its bench-stable nature facilitates straightforward handling and purification, making it well-suited for iterative synthesis of bioactive heterocycles and API intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   47.03
  • LogP   1.2476
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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