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CS-W001157 4
Total: USD 88.00

Methyl 1H-pyrrole-2-carboxylate

  • CAS No. 1193-62-0

  • Cat. No. CS-W013518
  • Purity≥98%
  • MDL No.MFCD00817048

*For research and further manufacturing use only, not for direct human use.

Methyl 1H-pyrrole-2-carboxylate|CS-W013518

Structure of 1193-62-0

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General Information

  • CAS No. 1193-62-0
  • Cat. No. CS-W013518
  • Purity ≥98%
  • MDL No. MFCD00817048
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇NO₂
  • Molecular Weight 125.13
  • Synonym(s) None
  • SMILES O=C(C1=CC=CN1)OC

Description

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques. Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.Key Features:Industry-standard 2O-TBDMS protective groupConsistent lot-to-lot purity and performanceCompatible with deprotection methods based on methylamine or AMAStandard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are btained with activator 42Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap AManufactured under a certified ISO 9001 quality systemDMT-2O-TBDMS-rC(ac) Phosphoramidite is configured for MerMade Synthesizers.

Synthesis

  • Route1
    • null|null
      67-56-1
    • In-stock
      Pyrrole-2-carboxylic acid|CS-W001963
      634-97-9
    • ~90%
    • In-stock
      Methyl 1H-pyrrole-2-carboxylate|CS-W013518
      1193-62-0

    References

    • Ruest, Luc; Menard, Hugues; Moreau, Vincent; Laplante, Francois Canadian Journal of Chemistry, 2002 , vol. 80, # 12 p. 1662 - 1667
  • Route2
    • In-stock
      2-(Trichloroacetyl)-1H-pyrrole|CS-W008918
      35302-72-8
    • null|null
      124-41-4
    • ~89%
    • In-stock
      Methyl 1H-pyrrole-2-carboxylate|CS-W013518
      1193-62-0

    References

    • Wischang, Diana; Hartung, Jens Tetrahedron, 2011 , vol. 67, # 22 p. 4048 - 4054
  • Route3

    References

    • Narayana Murthy; Nageswar Tetrahedron Letters, 2011 , vol. 52, # 34 p. 4481 - 4484

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   42.09
  • LogP   0.8013
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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