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CS-W001157 4
Total: USD 88.00

2- Methyldihydro-2H-pyran-4(3H)-one

  • CAS No. 1193-20-0

  • Cat. No. CS-W004274
  • Purity≥95%
  • MDL No.MFCD15071428

*For research and further manufacturing use only, not for direct human use.

2- Methyldihydro-2H-pyran-4(3H)-one|CS-W004274

Structure of 1193-20-0

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General Information

  • CAS No. 1193-20-0
  • Cat. No. CS-W004274
  • Purity ≥95%
  • MDL No. MFCD15071428
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₂
  • Molecular Weight 114.14
  • Synonym(s) 2-Methyloxan-4-one
  • SMILES O=C1CCOC(C1)C

Description

2-Methyldihydro-2H-pyran-4(3H)-one features a reactive γ-lactone moiety paired with a methyl-substituted dihydropyran ring, enabling direct incorporation into complex molecular architectures. This bench-stable scaffold serves as a key building block for natural product synthesis and bioactive molecule development.

Application

2-Methyldihydro-2H-pyran-4(3H)-one serves as a versatile synthetic intermediate for oxygenated heterocycles, enabling efficient access to substituted pyran rings via standard functional group manipulations. Its enolizable carbonyl and alkene functionalities facilitate Michael additions, aldol reactions, and transition-metal-catalyzed couplings. Bench-stable and amenable to purification by recrystallization or column chromatography, it functions reliably in multi-step synthesis workflows.

Synthesis

  • Route1
    • null|null
      19185-89-8
    • ~57%
    • In-stock
      2- Methyldihydro-2H-pyran-4(3H)-one|CS-W004274
      1193-20-0

    References

    • GALDERMA RESEARCH andamp; DEVELOPMENT; BOITEAU, Jean-Guy; PASCAL, Jean-Claude Patent: WO2010/63773 A1, 2010 ; Location in patent: Page/Page column 20-21 ; WO 2010/063773 A1
  • Route2

    References

    • Senda, Yasuhisa; Okamura, Kazue; Kuwahara, Mayumi; Ide, Masatoshi; Itoh, Hiroki; Ishiyama, Jun-Ichi Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999), 1992 , # 2 p. 799 - 803
  • Route3
    • null|null
      821-08-9
    • ~%
    • In-stock
      2- Methyldihydro-2H-pyran-4(3H)-one|CS-W004274
      1193-20-0

    References

    • Nasarow; Sarezkaja Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1942 , p. 200,201, 207 Chem.Abstr., 1945 , p. 1619 Full Text Show Details Nasarow et al. Zhurnal Obshchei Khimii, 1958 , vol. 28, p. 2746,2751; engl. Ausg. S. 2771, 2776

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.3
  • LogP   0.7544
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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