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CS-W001157 4
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2-(Benzofuran-7-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 1192755-14-8

  • Cat. No. CS-0041499
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-(Benzofuran-7-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-0041499

Structure of 1192755-14-8

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General Information

  • CAS No. 1192755-14-8
  • Cat. No. CS-0041499
  • Purity ≥97%
  • MDL No. None
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇BO₃
  • Molecular Weight 244.09
  • Synonym(s) Benzofuran-7-boronic acid pinacol ester
  • SMILES CC1(C)C(C)(C)OB(C2=C3OC=CC3=CC=C2)O1

Description

This boronate ester integrates a benzofuran-7-yl moiety with a sterically shielded tetramethyl-1,3,2-dioxaborolane group, delivering high stability and reactivity in cross-coupling transformations. The electron-rich aromatic system enhances coupling efficiency under standard conditions.

Application

2-(Benzofuran-7-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. Its tetramethyl-substituted dioxaborolane moiety enhances air and moisture stability while enabling efficient coupling with aryl and heteroaryl halides. The benzofuran-7-yl group provides a versatile scaffold for constructing biologically relevant heterocycles and functionalized aromatic systems in medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   31.6
  • LogP   2.732
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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