2,5-Dichloro-4-methylpyrimidine

Name: 2,5-Dichloro-4-methylpyrimidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1192064-63-3
Cat. No. CS-W006034
Purity≥95%
MDL No.MFCD13193656

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2,5-Dichloro-4-methylpyrimidine|CS-W006034

Structure of 1192064-63-3

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General Information

CAS No. 1192064-63-3
Cat. No. CS-W006034
Purity ≥95%
MDL No. MFCD13193656
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₄Cl₂N₂
Molecular Weight 163.01
Synonym(s) 2,5-Dichloro-4-methyl-pyrimidine
SMILES ClC1=NC=C(C(=N1)C)Cl

Description

2,5-Dichloro-4-methylpyrimidine serves as a reactive heterocyclic scaffold for nucleophilic substitution and cross-coupling processes. The electron-deficient pyrimidine ring, flanked by chlorine atoms at C2 and C5, enables selective functionalization under mild conditions. This bench-stable derivative integrates readily into pharmaceutical intermediates and agrochemical frameworks via Pd-catalyzed transformations.

Application

2,5-Dichloro-4-methylpyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient construction of pyrimidine-based scaffolds. Its electrophilic chlorine atoms facilitate nucleophilic substitution reactions under mild conditions, while the methyl group enhances metabolic stability and modulates electronic properties. The compound exhibits excellent bench stability and compatibility with diverse functional groups, making it ideal for modular synthesis workflows.

Synthesis

Route1
- 75-16-1
- In-stock
  
  5750-76-5
- ~65%
- In-stock
  
  1192064-63-3
References
- JANSSEN PHARMACEUTICA NV; BRANSTETTER, Bryan, James; LETAVIC, Michael, A.; LY, Kiev, S.; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHAH, Chandravadan, R.; SHIREMAN, Brock, T. Patent: WO2011/50202 A1, 2011 ; Location in patent: Page/Page column 57 ; WO 2011/050202 A1
Route2
- 75-16-1
- In-stock
  
  5750-76-5
- ~%
- In-stock
  
  1192064-63-3
- 75712-73-1
References
- WO2009/129036 A1, ; Page/Page column 80-81 ; WO 2009/129036 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 25.78
LogP 2.09182
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2,5-Dichloro-4-methylpyrimidine

CAS No. 1192064-63-3

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