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CS-W001157 4
Total: USD 88.00

4,4'-Difluoro-2,2'-bipyridine

  • CAS No. 1189458-67-0

  • Cat. No. CS-0160931
  • Molecule weight192.17
  • Purity≥98%
  • MDL No.MFCD11042493

*For research and further manufacturing use only, not for direct human use.

4,4'-Difluoro-2,2'-bipyridine|CS-0160931

Structure of 1189458-67-0

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General Information

  • CAS No. 1189458-67-0
  • Cat. No. CS-0160931
  • Purity ≥98%
  • MDL No. MFCD11042493
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₆F₂N₂
  • Molecular Weight 192.17
  • Synonym(s) None
  • SMILES FC=1C=CN=C(C1)C=2N=CC=C(F)C2

Description

4,4'-Difluoro-2,2'-bipyridine features a rigid bidentate scaffold with fluorine substituents that enhance electron deficiency and improve solubility in polar solvents. This configuration enables efficient coordination to transition metals in catalytic systems, particularly in photoredox and cross-coupling applications. The molecule exhibits bench-stable handling under standard conditions and integrates readily into complex ligand architectures.

Application

4,4'-Difluoro-2,2'-bipyridine serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl architectures under palladium- or nickel-mediated conditions. The difluorinated substitution pattern enhances both electronic modulation and metabolic stability in target scaffolds, while the bipyridyl core provides strong chelation for metal complexes. Bench-stable and readily purified by column chromatography, it functions effectively in standard synthetic workflows for pharmaceutical and materials chemistry applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   2.4218
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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