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CS-W001157 4
Total: USD 88.00

4-Bromo-8-(trifluoromethoxy)quinoline

  • CAS No. 1189105-60-9

  • Cat. No. CS-0041126
  • Molecule weight292.05
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-8-(trifluoromethoxy)quinoline|CS-0041126

Structure of 1189105-60-9

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General Information

  • CAS No. 1189105-60-9
  • Cat. No. CS-0041126
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₅BrF₃NO
  • Molecular Weight 292.05
  • Synonym(s) 4-Bromo-8-trifluoromethoxyquinoline
  • SMILES FC(F)(F)OC1=C2N=CC=C(Br)C2=CC=C1

Description

4-Bromo-8-(trifluoromethoxy)quinoline is a fluorinated quinoline derivative featuring a bromine substituent at the 4-position and a trifluoromethoxy group at the 8-position. This combination imparts enhanced electron-withdrawing character, improved metabolic stability, and favorable solubility for use in transition metal-catalyzed cross-coupling reactions. The molecule’s rigid aromatic core supports efficient π-stacking interactions, making it a valuable scaffold in medicinal chemistry and materials science applications.

Application

4-Bromo-8-(trifluoromethoxy)quinoline serves as a versatile building block in medicinal chemistry and catalytic cross-coupling reactions. The bromo group enables palladium-catalyzed coupling with boronic acids, amines, and other nucleophiles, while the trifluoromethoxy substituent enhances metabolic stability and modulates lipophilicity. Its bench-stable nature and compatibility with standard reaction conditions facilitate efficient synthesis of complex heterocyclic scaffolds for drug discovery applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   22.12
  • LogP   3.8959
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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