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CS-W001157 4
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tert-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate

  • CAS No. 118811-03-3

  • Cat. No. CS-0075718
  • Purity≥95%
  • MDL No.MFCD03701252

*For research and further manufacturing use only, not for direct human use.

tert-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate|CS-0075718

Structure of 118811-03-3

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General Information

  • CAS No. 118811-03-3
  • Cat. No. CS-0075718
  • Purity ≥95%
  • MDL No. MFCD03701252
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₃NO₃
  • Molecular Weight 229.32
  • Synonym(s) 1-Boc-2-(2-hydroxyethyl)-piperidine
  • SMILES O=C(OC(C)(C)C)N(CCCC1)C1CCO

Description

tert-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate features a piperidine core with a hydroxylated alkyl side chain, offering a bifunctional handle for conjugation. The tert-butyl ester provides stability and ease of removal under mild acidic conditions, enabling efficient incorporation into complex molecular architectures. This compound serves as a key building block in medicinal chemistry and peptide synthesis.

Application

tert-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate serves as a versatile piperidine scaffold with orthogonal functionality, enabling straightforward derivatization at both the nitrogen and hydroxyl positions. The tert-butyl carbamate group provides bench stability and ease of removal under mild acidic conditions, while the pendant hydroxyethyl moiety facilitates conjugation via esterification, ether formation, or oxidation to aldehyde for further functionalization. This dual-functional handle supports modular synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • Rouden, Jacques; Seitz, Thomas; Lemoucheux, Laurent; Lasne, Marie-Claire Journal of Organic Chemistry, 2004 , vol. 69, # 11 p. 3787 - 3793
  • Route2

    References

    • Schering Corporation Patent: US6362188 B1, 2002 ; US 6362188 B1
  • Route3
    • In-stock
      2-Piperidineethanol|CS-W001979
      1484-84-0
    • null|null
      41840-28-2
    • ~97%
    • In-stock
      tert-Butyl 2-(2-hydroxyethyl)piperidine-1-carboxylate|CS-0075718
      118811-03-3

    References

    • Takeda Chemical Industries, Ltd. Patent: EP278621 B1, 1991 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS09
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H320-H400
Precautionary Statements : P264-P270-P273-P330-P391-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.77
  • LogP   2.1584
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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