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CS-W001157 4
Total: USD 88.00

5-(Methylsulfonyl)picolinic acid

  • CAS No. 1186663-48-8

  • Cat. No. CS-0042957
  • Molecule weight201.20
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

5-(Methylsulfonyl)picolinic acid|CS-0042957

Structure of 1186663-48-8

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General Information

  • CAS No. 1186663-48-8
  • Cat. No. CS-0042957
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇NO₄S
  • Molecular Weight 201.20
  • Synonym(s) 5-(Methylsulfonyl)-2-pyridinecarboxylic Acid
  • SMILES O=C(O)C1=NC=C(S(=O)(C)=O)C=C1

Description

5-(Methylsulfonyl)picolinic acid features a pyridine ring bearing a methylsulfonyl group at the 5-position and a carboxylic acid at the 3-position, delivering enhanced solubility and metabolic stability. This dual functionality enables direct incorporation into bioconjugation workflows and medicinal chemistry campaigns requiring polar, bench-stable scaffolds.

Application

5-(Methylsulfonyl)picolinic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through its compatibility with standard coupling and functionalization reactions. The methylsulfonyl group enhances solubility and metabolic stability, while the picolinic acid scaffold facilitates chelation and hydrogen bonding in target-directed design. Its bench-stable nature and ease of purification support efficient workflow integration in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   84.33
  • LogP   0.1833
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   2

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