3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

Name: 3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1186608-73-0
Cat. No. CS-0051272
Purity≥95%
MDL No.MFCD13193614

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-amine|CS-0051272

Structure of 1186608-73-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 1186608-73-0
Cat. No. CS-0051272
Purity ≥95%
MDL No. MFCD13193614
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈N₄
Molecular Weight None
Synonym(s) 3-Methyl-1H-pyrazolo[3,4-b]pyridine-5-amine
SMILES CC1=NNC2=C1C=C(N)C=N2

Description

3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-amine features a fused heterocyclic core with a pendant amine and methyl group, offering enhanced electron density at the pyridine nitrogen. This scaffold enables direct incorporation into kinase inhibitors and bioactive small molecules, serving as a robust platform for medicinal chemistry optimization under standard bench conditions.

Application

3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-amine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to kinase inhibitor scaffolds and other bioactive architectures. Its electron-rich pyrazolopyridine core exhibits robust bench stability, facilitates straightforward functionalization at the 5-amino and 3-methyl positions, and demonstrates compatibility with standard coupling reactions, protecting group strategies, and late-stage diversification protocols common in API development.

Synthesis

Route1
- In-stock
  
  62908-83-2
- ~94%
- In-stock
  
  1186608-73-0
References
- ARRAY BIOPHARMA INC.; GENENTECH, INC.; AHRENDT, Kateri A.; BUCKMELTER, Alexandre J.; DE MEESE, Jason; GRINA, Jonas; HANSEN, Joshua D.; LAIRD, Ellen R.; LUNGHOFER, Paul; MORENO, David; NEWHOUSE, Brad; REN, Li; SEO, Jeongbeob; TIAN, Hongqi; WENGLOWSKY, Steven Mark; FENG, Bainian; GUNZNER, Janet; MALESKY, Kim; MATHIEU, Simon; RUDOLPH, Joachim; WEN, Zhaoyang; YOUNG, Wendy B. Patent: WO2009/111279 A1, 2009 ; Location in patent: Page/Page column 84 ; WO 2009/111279 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 67.59
LogP 0.84852
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 0

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Key Words

1186608-73-0 sigma1186608-73-0 manufacturer1186608-73-0 price1186608-73-0 structure1186608-73-0 SDSbuy 1186608-73-01186608-73-0 supplier1186608-73-0 uses1186608-73-0 molecular weightprice of 1186608-73-01186608-73-0 chemical name formula of 1186608-73-0

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-amine

CAS No. 1186608-73-0

Recommended Products