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(1-Methyl-1H-pyrazol-4-yl)methanamine dihydrochloride

  • CAS No. 1185299-72-2

  • Cat. No. CS-0053646
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(1-Methyl-1H-pyrazol-4-yl)methanamine dihydrochloride|CS-0053646

Structure of 1185299-72-2

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General Information

  • CAS No. 1185299-72-2
  • Cat. No. CS-0053646
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁Cl₂N₃
  • Molecular Weight 184.07
  • Synonym(s) C-(1-Methyl-1H-pyrazol-4-yl)-methylaminedihydrochloride
  • SMILES CN1C=C(C=N1)CN.Cl.Cl

Description

This bench-stable dihydrochloride salt features a methyl-substituted pyrazole core linked to a primary amine, delivering enhanced solubility and predictable protonation behavior. The functionalized scaffold integrates readily into medicinal chemistry campaigns, enabling efficient access to bioactive heterocycles through nucleophilic coupling or reductive amination pathways.

Application

(1-Methyl-1H-pyrazol-4-yl)methanamine dihydrochloride serves as a versatile building block for pyrazole-based pharmaceutical intermediates, enabling efficient access to diverse heterocyclic scaffolds. Its bifunctional nature—combining a nucleophilic amine with a readily derivatizable pyrazole ring—facilitates coupling reactions and cyclizations under standard conditions. The dihydrochloride salt enhances bench stability and solubility, simplifying handling and purification in synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P363-P405-P501

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Computational Chemistry Data

  • TPSA   43.84
  • LogP   0.7224
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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