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Structure of 1184918-22-6
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Thalidomide-NH-PEG4-COOH is a PROTAC linker featuring a thalidomide, a hydrophilic PEG spacer, and a carboxylic acid. Thalidomide recruits E3 Ligase for the ubiquitinylation and subsequent destruction of a given protein. The carboxylic acid is reactive towards amines and alcohols with the use of coupling reagents such as EDC or HATU.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H302-H314
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Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P363-P405-P501
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Lot numbers can be found on the outside label of a product: