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CS-W001157 4
Total: USD 88.00

1,2,4,5-Tetrazine-3,6-dicarboxylic acid

  • CAS No. 117943-07-4

  • Cat. No. CS-0565030
  • Purity≥98%
  • MDL No.MFCD04000257

*For research and further manufacturing use only, not for direct human use.

1,2,4,5-Tetrazine-3,6-dicarboxylic acid|CS-0565030

Structure of 117943-07-4

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General Information

  • CAS No. 117943-07-4
  • Cat. No. CS-0565030
  • Purity ≥98%
  • MDL No. MFCD04000257
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂N₄O₄
  • Molecular Weight 170.08
  • Synonym(s) None
  • SMILES O=C(O)C1=NN=C(N=N1)C(=O)O

Description

1,2,4,5-Tetrazine-3,6-dicarboxylic acid features a highly electron-deficient tetrazine core paired with two carboxylic acid groups, enabling efficient bioorthogonal conjugation. This scaffold integrates readily into probe designs for live-cell labeling and molecular imaging, offering fast reaction kinetics with strained cyclooctynes under physiological conditions.

Application

1,2,4,5-Tetrazine-3,6-dicarboxylic acid serves as a versatile building block for bioorthogonal conjugation and heterocyclic synthesis. Its electron-deficient tetrazine core enables efficient inverse electron-demand Diels–Alder (IEDDA) reactions with strained dienophiles, facilitating rapid labeling under physiological conditions. The dicarboxylic acid functionality enhances solubility and provides handles for derivatization or solid-phase immobilization, supporting applications in probe development, peptide conjugation, and targeted drug delivery systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   126.16
  • LogP   -1.337
  • H_Acceptors   6
  • H_Donors   2
  • Rotatable_Bonds   2

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  • 1,2,4,5-Tetrazine-3,6-dicarboxylic acid sigma1,2,4,5-Tetrazine-3,6-dicarboxylic acid manufacturer1,2,4,5-Tetrazine-3,6-dicarboxylic acid price1,2,4,5-Tetrazine-3,6-dicarboxylic acid structure1,2,4,5-Tetrazine-3,6-dicarboxylic acid SDSbuy 1,2,4,5-Tetrazine-3,6-dicarboxylic acid1,2,4,5-Tetrazine-3,6-dicarboxylic acid supplier1,2,4,5-Tetrazine-3,6-dicarboxylic acid uses1,2,4,5-Tetrazine-3,6-dicarboxylic acid molecular weightprice of 1,2,4,5-Tetrazine-3,6-dicarboxylic acid1,2,4,5-Tetrazine-3,6-dicarboxylic acid chemical name formula of 1,2,4,5-Tetrazine-3,6-dicarboxylic acid
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