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CS-W001157 4
Total: USD 88.00

5-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline

  • CAS No. 1176414-91-7

  • Cat. No. CS-0225557
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

5-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline|CS-0225557

Structure of 1176414-91-7

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Description

5-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline delivers a brominated, N-methylated tetrahydroisoquinoline scaffold with enhanced electrophilic reactivity at the aromatic ring. This bench-stable compound integrates readily into transition-metal-catalyzed coupling reactions and serves as a key intermediate in the synthesis of bioactive alkaloids and pharmaceutical candidates.

Application

5-Bromo-1-methyl-1,2,3,4-tetrahydroisoquinoline serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its well-defined aryl bromide functionality. The tetrahydroisoquinoline core provides a rigid, bioactive scaffold with favorable pharmacokinetic properties. Its methylated nitrogen enhances metabolic stability and improves solubility, while the bromine substituent allows for selective functionalization under standard coupling conditions. This compound facilitates efficient access to complex heterocyclic architectures relevant to CNS-targeted therapeutics and kinase inhibitors.

General Information

  • CAS No. 1176414-91-7
  • Cat. No. CS-0225557
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂BrN
  • Molecular Weight 226.11
  • Synonym(s) None
  • SMILES CC1NCCC2=C1C=CC=C2Br

Computational Chemistry Data

  • TPSA   12.03
  • LogP   2.6558
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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