6-Chloro-2-(trifluoromethyl)pyridin-3-amine

Name: 6-Chloro-2-(trifluoromethyl)pyridin-3-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 117519-13-8
Cat. No. CS-0054544
Purity≥98%
MDL No.MFCD18261523

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

6-Chloro-2-(trifluoromethyl)pyridin-3-amine|CS-0054544

Structure of 117519-13-8

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 117519-13-8
Cat. No. CS-0054544
Purity ≥98%
MDL No. MFCD18261523
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₄ClF₃N₂
Molecular Weight 196.56
Synonym(s) None
SMILES NC1=CC=C(N=C1C(F)(F)F)Cl

Description

6-Chloro-2-(trifluoromethyl)pyridin-3-amine delivers a potent electron-deficient pyridine scaffold with orthogonal functional handles. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the chloro substituent enables palladium-catalyzed coupling reactions. This molecule serves as a key building block in medicinal chemistry for targeted kinase inhibitors and bioactive heterocycles.

Application

6-Chloro-2-(trifluoromethyl)pyridin-3-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of heterocyclic scaffolds via palladium-catalyzed cross-coupling reactions. The chloro group facilitates C–C and C–N bond formation under standard conditions, while the trifluoromethyl and amine functionalities offer enhanced metabolic stability and hydrogen-bonding capacity. Bench-stable and compatible with common protecting groups, it supports scalable synthesis of kinase inhibitors and other bioactive molecules.

Synthesis

Route1
- In-stock
  
  887144-97-0
- In-stock
  
  5350-93-6
- ~47%
- In-stock
  
  117519-13-8
References
- Wiehn, Matthias S.; Vinogradova, Ekaterina V.; Togni, Antonio Journal of Fluorine Chemistry, 2010 , vol. 131, # 9 p. 951 - 957
Route2
- In-stock
  
  117519-19-4
- ~%
- In-stock
  
  117519-13-8
References
- PHENEX PHARMACEUTICALS AG; STEENECK, Christoph; KINZEL, Olaf; GEGE, Christian; KLEYMANN, Gerald; HOFFMANN, Thomas Patent: WO2013/79223 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3259
Class : 8	Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 38.91
LogP 2.336
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

117519-13-8 sigma117519-13-8 manufacturer117519-13-8 price117519-13-8 structure117519-13-8 SDSbuy 117519-13-8117519-13-8 supplier117519-13-8 uses117519-13-8 molecular weightprice of 117519-13-8117519-13-8 chemical name formula of 117519-13-8

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

6-Chloro-2-(trifluoromethyl)pyridin-3-amine

CAS No. 117519-13-8

Recommended Products