6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid

Name: 6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 1173003-61-6
Cat. No. CS-0075872
Purity≥98%
MDL No.None

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Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid|CS-0075872

Structure of 1173003-61-6

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General Information

CAS No. 1173003-61-6
Cat. No. CS-0075872
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₈N₂O₃
Molecular Weight 168.15
Synonym(s) 5H,6H,7H-pyrazolo[3,2-b][1,3]oxazine-3-carboxylic acid
SMILES O=C(O)C1=C2N(N=C1)CCCO2

Description

6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid features a fused heterocyclic core with a carboxylic acid handle, enabling direct incorporation into bioactive scaffolds. This stable, electron-deficient framework supports modular derivatization in medicinal chemistry and offers favorable solubility for solution-phase synthesis.

Application

6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid serves as a versatile heterocyclic building block for medicinal chemistry and synthetic organic applications. Its fused tricyclic core exhibits robust bench stability and tolerates a range of functional groups, enabling efficient derivatization via amide coupling, esterification, or nucleophilic substitution. The carboxylic acid moiety facilitates conjugation in peptide synthesis and prodrug design, while the scaffold provides structural rigidity beneficial for target engagement in kinase and receptor modulators.

Synthesis

Route1
- 1173003-60-5
- ~96%
- In-stock
  
  1173003-61-6
References
- RENOVIS, INS.; PFIZER LIMITED Patent: WO2009/89057 A1, 2009 ; Location in patent: Page/Page column 56-57 ; WO 2009/089057 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 64.35
LogP 0.3638
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrazole compounds

Key Words

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6,7-Dihydro-5H-pyrazolo[5,1-b][1,3]oxazine-3-carboxylic acid

CAS No. 1173003-61-6

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