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CS-W001157 4
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2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride

  • CAS No. 1171331-39-7

  • Cat. No. CS-0136950
  • Purity≥97%
  • MDL No.MFCD12197070

*For research and further manufacturing use only, not for direct human use.

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride|CS-0136950

Structure of 1171331-39-7

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General Information

  • CAS No. 1171331-39-7
  • Cat. No. CS-0136950
  • Purity ≥97%
  • MDL No. MFCD12197070
  • Storage 4°C, sealed storage, away from moisture and light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈ClF₃N₂O
  • Molecular Weight 192.57
  • Synonym(s) Fluralaner-014
  • SMILES O=C(NCC(F)(F)F)CN.[H]Cl

Description

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride delivers a trifluoromethylated amine scaffold with enhanced solubility and metabolic stability. The electron-withdrawing trifluoromethyl group modulates basicity while maintaining compatibility with standard peptide coupling protocols. This bench-stable salt form facilitates direct incorporation into bioactive molecule synthesis.

Application

2-Amino-N-(2,2,2-trifluoroethyl)acetamide hydrochloride serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated amide-containing scaffolds. The trifluoroethyl group imparts enhanced metabolic stability and lipophilicity, while the aminoacetamide functionality facilitates downstream coupling reactions. Its crystalline hydrochloride salt form ensures excellent bench stability, ease of handling, and straightforward purification—key attributes for scalable API development and high-throughput screening workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.12
  • LogP   0.0454
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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