(S)-tert-Butyl 3-(4-aminophenyl)piperidine-1-carboxylate

Name: (S)-tert-Butyl 3-(4-aminophenyl)piperidine-1-carboxylate
Brand: ChemScene
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CAS No. 1171197-20-8
Cat. No. CS-0022119
Purity≥97%
MDL No.MFCD27921195

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(S)-tert-Butyl 3-(4-aminophenyl)piperidine-1-carboxylate|CS-0022119

Structure of 1171197-20-8

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Description

(S)-tert-Butyl 3-(4-aminophenyl)piperidine-1-carboxylate is a chiral building block featuring a piperidine core linked to a para-aminophenyl group, enabling direct incorporation into bioactive molecule scaffolds. The tert-butyl ester moiety offers enhanced stability and ease of deprotection under mild acidic conditions. This compound serves as a key intermediate in the synthesis of pharmaceutical agents targeting neurological disorders.

Application

(S)-tert-Butyl 3-(4-aminophenyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling the synthesis of piperidine-based scaffolds prevalent in CNS-targeted therapeutics. The protected amine and aryl functionality offer orthogonal reactivity, facilitating late-stage functionalization via Suzuki-Miyaura coupling or amide bond formation. Bench-stable and readily purified by flash chromatography, it functions efficiently in multi-step syntheses requiring high regioselectivity and stereochemical integrity.

General Information

CAS No. 1171197-20-8
Cat. No. CS-0022119
Purity ≥97%
MDL No. MFCD27921195
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₂₄N₂O₂
Molecular Weight 276.37
Synonym(s) tert-butyl (S)-3-(4-aminophenyl)piperidine-1-carboxylate
SMILES O=C(N1C[C@H](C2=CC=C(N)C=C2)CCC1)OC(C)(C)C

Computational Chemistry Data

TPSA 55.56
LogP 3.3833
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Life Science ADC Related Compound Payload

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Biochemicals and Reagents Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

Biochemistry Pharmaceutical Development and Drug Discovery Research Antibody-Drug Conjugates (ADC) Preparation Research Reagents Payload (Drug) Candidates

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(S)-tert-Butyl 3-(4-aminophenyl)piperidine-1-carboxylate

CAS No. 1171197-20-8

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