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tert-Butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate

  • CAS No. 1171125-92-0

  • Cat. No. CS-0048536
  • Molecule weight230.30
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

tert-Butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate|CS-0048536

Structure of 1171125-92-0

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General Information

  • CAS No. 1171125-92-0
  • Cat. No. CS-0048536
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₂₂N₂O₃
  • Molecular Weight 230.30
  • Synonym(s) None
  • SMILES CO[C@H]1CN(CC[C@H]1N)C(=O)OC(C)(C)C

Description

tert-Butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate is a stereochemically defined piperidine derivative featuring a bench-stable tert-butoxycarbonyl group and a methoxy-substituted carbon. This configuration enables selective incorporation into complex molecular architectures, particularly in the synthesis of bioactive alkaloids and pharmaceutical intermediates. The amino and methoxy functionalities offer distinct handles for downstream functionalization.

Application

tert-Butyl (3S,4R)-4-amino-3-methoxypiperidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of bioactive piperidine scaffolds. The protected amine and methoxy group enable orthogonal functionalization, while the tert-butyl carbamate offers bench stability and facile deprotection under mild acidic conditions. Its well-defined stereochemistry supports reproducible access to complex heterocyclic frameworks in medicinal chemistry campaigns.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   64.79
  • LogP   0.9695
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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