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CS-W001157 4
Total: USD 88.00

3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid

  • CAS No. 1163729-49-4

  • Cat. No. CS-W018788
  • Molecule weight184.11
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid|CS-W018788

Structure of 1163729-49-4

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General Information

  • CAS No. 1163729-49-4
  • Cat. No. CS-W018788
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₇F₃O₃
  • Molecular Weight 184.11
  • Synonym(s) 3-Hydroxy-3-(trifluoromethyl)
  • SMILES O=C(C1CC(C(F)(F)F)(O)C1)O

Description

This cyclobutanecarboxylic acid derivative features a trifluoromethyl group and a hydroxyl substituent on the same carbon, creating a sterically congested, electron-deficient center. The molecule combines enhanced metabolic stability with high polarity, enabling efficient integration into bioactive scaffolds. Its bench-stable, moisture-tolerant profile supports direct use in synthetic transformations and medicinal chemistry campaigns.

Application

3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive cyclobutane scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid and adjacent hydroxyl functionalities provide orthogonal handles for derivatization. The compound exhibits bench stability and facilitates efficient functional group interconversions in standard synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   57.53
  • LogP   0.7744
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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