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Structure of 1163729-49-4
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This cyclobutanecarboxylic acid derivative features a trifluoromethyl group and a hydroxyl substituent on the same carbon, creating a sterically congested, electron-deficient center. The molecule combines enhanced metabolic stability with high polarity, enabling efficient integration into bioactive scaffolds. Its bench-stable, moisture-tolerant profile supports direct use in synthetic transformations and medicinal chemistry campaigns.
3-Hydroxy-3-(trifluoromethyl)cyclobutanecarboxylic acid serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive cyclobutane scaffolds. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid and adjacent hydroxyl functionalities provide orthogonal handles for derivatization. The compound exhibits bench stability and facilitates efficient functional group interconversions in standard synthetic workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: