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CS-W001157 4
Total: USD 88.00

Imidazo[1,2-a]pyridine-6-carbaldehyde

  • CAS No. 116355-16-9

  • Cat. No. CS-0049337
  • Purity≥97%
  • MDL No.MFCD07772808

*For research and further manufacturing use only, not for direct human use.

Imidazo[1,2-a]pyridine-6-carbaldehyde|CS-0049337

Structure of 116355-16-9

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General Information

  • CAS No. 116355-16-9
  • Cat. No. CS-0049337
  • Purity ≥97%
  • MDL No. MFCD07772808
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆N₂O
  • Molecular Weight 146.15
  • Synonym(s) IMidazo[1,2-a]pyridine-6-carboxaldehyde(9CI)/116355-16-9
  • SMILES O=CC1=CN2C=CN=C2C=C1

Description

Imidazo[1,2-a]pyridine-6-carbaldehyde features a fused heterocyclic core with a strategically positioned aldehyde group, enabling direct incorporation into bioactive molecule scaffolds. This electron-deficient platform facilitates efficient coupling reactions and serves as a key intermediate in the development of pharmaceutical candidates targeting kinase pathways.

Application

Imidazo[1,2-a]pyridine-6-carbaldehyde serves as a versatile building block for heterocyclic synthesis, enabling efficient access to biologically relevant scaffolds. Its aldehyde functionality facilitates reductive amination, Wittig reactions, and condensation processes under standard conditions. The molecule exhibits good bench stability and functional group tolerance, making it suitable for iterative synthesis in medicinal chemistry and process development workflows.

Synthesis

  • Route1

    References

    • US5444066 A1, ;
  • Route2

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 21 p. 6586 - 6590
  • Route3

    References

    • Journal of Organic Chemistry, , vol. 66, # 20 p. 6576 - 6584

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H317
Precautionary Statements : P261-P272-P280-P302+P352-P362+P364-P501

Quality Control

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Computational Chemistry Data

  • TPSA   34.37
  • LogP   1.1468
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   1

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