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4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride

  • CAS No. 116118-99-1

  • Cat. No. CS-0030493
  • Purity≥97%
  • MDL No.MFCD20489124

*For research and further manufacturing use only, not for direct human use.

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride|CS-0030493

Structure of 116118-99-1

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General Information

  • CAS No. 116118-99-1
  • Cat. No. CS-0030493
  • Purity ≥97%
  • MDL No. MFCD20489124
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀ClNO₂S
  • Molecular Weight 219.69
  • Synonym(s) 4,5,6,7-tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid,hydrochloride
  • SMILES O=C(C(S1)=CC2=C1CCNC2)O.[H]Cl

Description

This tetrahydrothienopyridine carboxylic acid hydrochloride features a rigid, electron-rich heterocyclic core that enhances solubility and metabolic stability. The carboxylic acid functionality enables direct coupling in peptide synthesis, while the hydrochloride salt ensures improved crystallinity and handling. Ideal for medicinal chemistry campaigns targeting kinase inhibitors and CNS-active compounds.

Application

4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its stable, bench-ready form facilitates direct use in amide coupling, esterification, and derivatization reactions. The carboxylic acid functionality enables conjugation with amines and alcohols under standard conditions, while the fused thienopyridine core provides structural rigidity and enhanced metabolic stability in bioactive molecule design.

Synthesis

  • Route1
    • Diethyl 6,7-dihydrothieno[3,2-c]pyridine-2,5(4h)-dicarboxylate|CS-0687961
      116119-00-7
    • ~30%
    • In-stock
      4,5,6,7-Tetrahydrothieno[3,2-c]pyridine-2-carboxylic acid hydrochloride|CS-0030493
      116118-99-1

    References

    • WO2009/124746 A1, ; Page/Page column 121 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   49.33
  • LogP   1.5138
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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