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CS-W001157 4
Total: USD 88.00

5-Bromopyrazolo[1,5-a]pyrimidine

  • CAS No. 1159981-95-9

  • Cat. No. CS-W005661
  • Purity≥95%
  • MDL No.MFCD11042744

*For research and further manufacturing use only, not for direct human use.

5-Bromopyrazolo[1,5-a]pyrimidine|CS-W005661

Structure of 1159981-95-9

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General Information

  • CAS No. 1159981-95-9
  • Cat. No. CS-W005661
  • Purity ≥95%
  • MDL No. MFCD11042744
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄BrN₃
  • Molecular Weight 198.02
  • Synonym(s) 5-bromanylpyrazolo[1,5-a]pyrimidine
  • SMILES BrC1=NC2=CC=NN2C=C1

Description

5-Bromopyrazolo[1,5-a]pyrimidine serves as a pivotal heterocyclic scaffold for medicinal chemistry and materials science. This brominated pyrazolopyrimidine integrates readily into diverse synthetic pathways, offering a robust platform for constructing bioactive compounds and functionalized polymers. Its electron-deficient core enables efficient coupling reactions, while its stability under standard conditions supports reliable handling in process development workflows.

Application

5-Bromopyrazolo[1,5-a]pyrimidine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions for the synthesis of biologically active heterocycles. Its bromine substituent facilitates efficient C–C and C–heteroatom bond formation under standard Suzuki, Stille, and Buchwald-Hartwig conditions. The pyrazolopyrimidine core provides a rigid, electron-deficient scaffold with proven utility in kinase inhibitor and antiviral agent development, offering excellent bench stability and compatibility with common purification methods.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   30.19
  • LogP   1.4918
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   0

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