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CS-W001157 4
Total: USD 88.00

7-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine

  • CAS No. 1159811-23-0

  • Cat. No. CS-0187258
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

7-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine|CS-0187258

Structure of 1159811-23-0

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General Information

  • CAS No. 1159811-23-0
  • Cat. No. CS-0187258
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClN₄
  • Molecular Weight 154.56
  • Synonym(s) 7-Chloro[1,2,4]triazolo[1,5-c]pyrimidine
  • SMILES C1=C(Cl)N=CN2C1=NC=N2

Description

7-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine is a heterocyclic scaffold featuring a chlorine atom at the 7-position, enhancing electrophilicity for downstream functionalization. This electron-deficient core integrates readily into medicinal chemistry libraries, serving as a key building block for kinase inhibitors and antiviral agents. The fused triazolopyrimidine system confers metabolic stability and favorable binding affinity in target-directed synthesis.

Application

7-Chloro-[1,2,4]triazolo[1,5-c]pyrimidine serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient construction of purine-like scaffolds. Its chlorine substituent facilitates nucleophilic substitution reactions, allowing for facile derivatization at the C7 position. The compound exhibits good bench stability and functional group tolerance, making it well-suited for use in parallel synthesis campaigns and API intermediate development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   43.08
  • LogP   0.7777
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   0

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