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CS-W001157 4
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4-Bromo-7-methyl-1H-indazole

  • CAS No. 1159511-74-6

  • Cat. No. CS-0056159
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromo-7-methyl-1H-indazole|CS-0056159

Structure of 1159511-74-6

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General Information

  • CAS No. 1159511-74-6
  • Cat. No. CS-0056159
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₇BrN₂
  • Molecular Weight 211.06
  • Synonym(s) 4-bromo-7-methyL
  • SMILES CC1=C2C(=C(C=C1)Br)C=NN2

Description

4-Bromo-7-methyl-1H-indazole features a bromine substituent at the 4-position and a methyl group at the 7-position on the indazole core, delivering enhanced electron-withdrawing character and improved solubility in organic media. This scaffold integrates readily into medicinal chemistry libraries, serving as a key building block for kinase inhibitors and bioactive heterocycles.

Application

4-Bromo-7-methyl-1H-indazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its stable bromo functionality. The methyl group at the 7-position enhances metabolic stability and modulates electronic properties, while the indazole core provides a rigid, bioisosteric scaffold for targeted protein inhibition. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis in API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P260-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   28.68
  • LogP   2.63382
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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