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CS-W001157 4
Total: USD 88.00

1-(4-Boronophenyl)cyclopropane-1-carboxylic acid

  • CAS No. 1159489-46-9

  • Cat. No. CS-0174541
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-(4-Boronophenyl)cyclopropane-1-carboxylic acid|CS-0174541

Structure of 1159489-46-9

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General Information

  • CAS No. 1159489-46-9
  • Cat. No. CS-0174541
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₁BO₄
  • Molecular Weight 206.00
  • Synonym(s) 1-(4-Boronophenyl)cyclopropanecarboxylic acid
  • SMILES OB(O)C1=CC=C(C2(C(O)=O)CC2)C=C1

Description

This cyclopropane carboxylic acid features a boronated phenyl group that enhances its utility in Suzuki-Miyaura cross-coupling reactions. The strained cyclopropyl scaffold imparts unique reactivity, while the boronic acid moiety enables stable, selective transformations under mild conditions. Ideal for constructing complex aryl architectures in medicinal chemistry and materials science.

Application

1-(4-Boronophenyl)cyclopropane-1-carboxylic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. The boronate group exhibits high stability and compatibility with diverse functional groups, while the cyclopropyl carboxylic acid moiety provides a rigid, stereochemically constrained scaffold useful in medicinal chemistry and target-oriented synthesis. Its bench-stable nature and ease of purification facilitate integration into multi-step synthetic sequences.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   77.76
  • LogP   -0.5174
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   3

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